Isolating surface-enhanced Raman scattering hot spots using multiphoton lithography


E. D. Diebold, P. Peng, and E. Mazur. 2009. “Isolating surface-enhanced Raman scattering hot spots using multiphoton lithography.” J. Am. Chem. Soc., 131, Pp. 16356–16357. Publisher's Version


We present a method for improving femtomole-level trace detection (10^9 molecules) using large-area surface-enhanced Raman scattering (SERS) substrates. Using multiphoton-induced exposure of a commercial photoresist, we physically limit the available molecular adsorption sites to only the electromagnetic hot spots on the substrate. This process prevents molecules from adsorbing to sites of weak SERS enhancement, while permitting adsorption to sites of extraordinary SERS enhancement. For a randomly adsorbed submonolayer of benzenethiol molecules the average Raman scattering cross section of the processed sample is 27 times larger than that of an unprocessed SERS substrate.
Last updated on 07/24/2019